0871 Outcomes in Overlap Syndrome of COPD and OSA: A Secondary Data Analysis of STAGES

Abstract Introduction Chronic obstructive pulmonary disease (COPD) and sleep apnea (OSA) are highly prevalent, termed Overlap Syndrome (OVS) when coexistent. Patient-reported outcomes (PROs) impaired in both COPD OSA alone, but their combined impact is unclear. We examined differences the of on PROs adults with without OSA. Methods Analyses included aged≥8 years polysomnographic (PSG) data from Stanford Technology Analytics Genomics Sleep (STAGES) study. created sets individuals COPD, matched up to 1:5 age±5 years, BMI±2.5 kg/m2, AHI±5 events/hour, sex. Among all sets, we estimated fatigue (Fatigue Severity Scale), sleepiness (Epworth Sleepiness anxiety (Generalized Anxiety Disorder Questionnaire), depression (Personal Health Questionnaire-9), insomnia (Insomnia Index), function (Functional Outcomes Questionnaire) using linear mixed effects models. also whether effect differed between those (AHI≥10 events/hour) (AHI< 10 Results Overall, 56 patients were a total 199 non-COPD controls (51.0% males). The sample was middle aged (55.8±11.8 years), overweight/obese (BMI 29.8±6.9 kg/m2), had mild/moderate (AHI 11.0±11.5 average; 26 (46.4%) cases an AHI≥10. patients, associated worse average (p< 0.05 for ESS [p=0.070]). AHI< 10, there no any PRO groups COPD. However, values among OSA, including (mean [95% CI] difference = 9.8 [2.9, 16.7], p=0.006), (2.8 [0.01, 5.7], p=0.050), (3.6 [1.1, 6.0], p=0.005), (4.4 [1.8, 7.0], p=0.001), (4.8 [2.0, 7.6], p=0.001) (-3.3 [-5.2, -1.5], p=0.001). Conclusion modified by OVS compared Identification through early screening crucial prompt treatment reduce symptom burden. Support (if any) T32HL07713 P01 HL094307